Oral Health

Oral Health 2022-04-22T15:50:49-04:00

Adjunct Treatment for Moderate to Severe Periodontitis

Perio-1 is a late-stage clinical asset with applications as an adjunct to scaling and root planing (SRP), for the treatment of moderate to severe chronic periodontitis. Perio-1 delivers fluorescent light energy (FLE) to the periodontal pockets to facilitate periodontal pocket debridement, and improves periodontal pocket and gum reattachment. Perio-1 is supported by multiple clinical studies, and an excellent safety profile.

What is Periodontitis?

Periodontitis, caused by plaque build-up on the teeth, is the most common cause of tooth loss in adults. It is characterized by the progressive, chronic  inflammation of the gums and surrounding tissue. In it’s mildest form, the disease is termed gingivitis, which is accompanied by swollen, bleeding gums.

According to the Centers for Disease Control and Prevention (CDC), 50% of Americans aged 30 or older have periodontitis with the prevalence increasing to 70% for adults aged 65 and older.

What is Scaling and Root Planing?

According to the Journal of Evidenced-Based Dental Practice, the scaling and root planing (SRP) procedure also known as deep cleaning remains the gold standard for the nonsurgical management of periodontitis. Scaling and root planing teeth is performed by either a dentist or a dental hygienist and may require several appointments depending on the amount of tartar build-up. Anesthesia is often required as patients generally experience tooth sensitivity, bleeding, discomfort and pain.

The procedure involves using a scaling tool to manually remove all plaque, tartar and bacterial toxins and deposits from the teeth and root surfaces. Then, root planning serves to smooth all rough areas on the roots’ surfaces, removing cementum and surface dentin. Smooth root surfaces halt bacteria from re-adhering underneath the gumline, which promotes firm and healthy reattachment of the gums.

Clinical benefits of Perio-1 as an SRP adjunct:

  • Facilitates periodontal pocket debridement and instrumentation
  • Decreases pain, bleeding and inflammation in the pockets and gums
  • Speeds up the SRP procedure
  • Reduces periodontal pocket depth (PPD)
  • Decreases clinical attachment levels/loss (CAL)

67% of investigators felt that incorporating Perio-1 into their Scaling and Root Planing (SRP) procedure made it easier with the rest noting no difference1


A reduction of at least 3mm in periodontal pocket depth (PPD) was observed in more than half of the Perio-1 group compared to 6% in the SRP alone group2


Perio-1 halts the progression of gum attachment loss by decreasing clinical attachment levels (CAL) by 54% compared to 16% in the SRP alone group2


Perio-1 patients felt less pain than patients who underwent SRP alone as demonstrated by a 78% decrease in the Visual Analogue Scale (VAS) pain scores2


According to investigators, Perio-1 led to a decrease in bleeding and inflammation in 77% of patients with the remaining 23% noting no change compared to SRP alone1

Data on File

(1) The evaluation of the clinical effects of the klox biophotonic perio-1 gel with an LED curing lamp as an adjunct to the non-surgical treatment of moderate to severe chronic periodontitis (CL-K1004-P001)

(2) Evaluation of the clinical effect of the klox biophotonic system as an adjunct to the non surgical treatment of chronic periodontitis (IIT-K1004-P001)