Technology 2019-10-23T12:41:48-04:00

Fluorescence Biomodulation

Klox Technologies proprietary technology platform utilizes Fluorescence Biomodulation (FB) technology to benefit patients suffering from various skin and soft tissue disorders. FB technology harnesses the power of fluorescence to trigger natural living biological systems. Current clinical programs have shown a high degree of efficacy and safety. Klox has developed, and is further developing, several easy to use, pathology-specific FB Systems to address conditions in the area of Wound Care, Dermatology, Animal Health and Oral Health. Our FB Systems have been designed to provide patients with a safe and comfortable experience with little to no downtime.

Klox’s FB Systems comprise a topically applied medium (currently in gel format) made up of light absorbing molecules activated by an LED device to generate fluorescence at a cellular level.

How to use the FB System

Action at the Subcellular and Molecular Level

FB technology provides a unique and dynamic energy output that allows for the stimulation of the mitochondria, the engine of the cells. In the mitochondria, cellular respiration occurs, and energy is created by converting oxygen into ATP. Within all cells, especially within their mitochondria, there are an abundance of photoreceptors, for example, flavins, iron-sulfur or heme centers, which can absorb fluorescence. Data on file shows that triggering FB results in an increase in mitochondrial number and size – this process is known as mitochondrial biogenesis1. These dynamic and morphological changes reflect an increase in energy supply.


T1 – Untreated

T1 – FB Treated


Excellent Safety Profile: After almost 10 years of clinical evaluations, there have been no reports of serious treatment related adverse events.

Non-Invasive: The FB Systems are only applied externally on the affected area; neither component is metabolized. Topical LAM product(s) have been formulated with rinse-off characteristics.

No Downtime: No pain, scaling or photosensitivity are associated with the FB Systems and patients have reported a comfortable and enjoyable Klox experience.

Ease-of-Use: The procedure can be performed by nurses and other medical personnel; training is simple and cost-effective. Feedback from physicians and nurses is positive with the FB technology being preferred over others.

1. Karu, Tiina I, et al. “Absorption Measurements of a Cell Monolayer Relevant to Phototherapy: Reduction of Cytochrome c Oxidase under near IR Radiation.” Journal of Photochemistry and Photobiomology B:Biology, vol. 81, no. 2, Nov. 2005, pp. 98–106.

2. Barolet, Daniel. “Light-Emitting Didoes (LEDs) in Dermatology.” Seminars in Cutaneous Medicine and Surgery, vol. 27, no. 4, Dec. 2008, pp. 227–238.

3. Gwynee, Peter J. “Light as a Broad-Spectrum Antimicrobial.” Seminars in Cutaneous Medicine and Surgerya , vol. 27, no. 4, Dec. 2008, pp. 227–238.

4. Passarella, Salvatore, and Karu, Tiina I. “Absorption of Monochromatic and Narrow Band Radiation in the Visible and near IR by Both Mitochondrial and Non-Mitochondrial Photoacceptors Results in Photobiomodulation.” Journal of Photochemistry and Photobiology B: Biology, vol. 140, 2014, pp. 344–358.