Oral Health

Poor oral health can have serious adverse effects on people’s lives – both functional and cosmetic. If left untreated, periodontal disease can lead to a host of problems, including tooth and bone loss.

The World Health Organization (WHO) estimates that 10-15% of adults worldwide suffer from advanced periodontal disease. And according to the Centers for Disease Control and Prevention (CDC), half of Americans age 30 or older have periodontal disease, including periodontitis, with the prevalence increasing to 70% for adults age 65 and older.

While professional procedures do exist, traditional periodontal treatments such as scaling and root planing can be quite painful, and may require frequent and regular follow-up treatments.

Periodontitis, the most common cause of adult tooth loss, is a condition caused by plaque buildup on the teeth. It is characterized by progressive and chronic infection and inflammation of the gums and surrounding tissue. If left untreated, this can cause destruction of the teeth’s supporting structures and lead to tooth and bone loss.

Based on its proprietary technology platform, Klox Technologies is developing PERIO-1 as a low-cost and non-invasive adjunct treatment to scaling and root planing.

  • Preliminary clinical evaluations have shown that the addition of PERIO-1 to scaling and root planning can improve the outcome in patients suffering from periodontitis.
  • Dentists involved in clinical trials anecdotally noted that the addition of PERIO-1 made scaling and root planing procedures easier and less time-consuming to perform.

Gingivitis, the precursor to periodontitis, is accompanied by swollen and bleeding gums. This can result in the formation of gaps, or periodontal pockets, between the teeth and gums that can harbor disease-causing bacteria. As the pockets grow deeper, the bacteria becomes inaccessible by daily oral hygiene practices, such as brushing and flossing. If gingivitis is left untreated, it can eventually lead to periodontitis.

We are furthering research and development of our PERIO-1 oral healthcare solution for the treatment of gingivitis.